Edoardo Gaude

Co-founder and Chief Executive Officer

I am a Science Entrepreneur with a background in Biochemistry and Diagnostics. My main interest is to develop healthcare academic research into impact innovations. My current focus includes diagnostics applications for large patient populations and therapeutics solutions for low and middle income countries. My free time is generally spent exploring the great outdoors.

Experience

Startup Accelerate Program

Cambridge (UK), Jan 2018 – current. Cambridge Judge Business School: Start and development of life science venture. Business development. Market research.

Co-Founder and CSO

Cambridge (UK), Nov 2017 – current. POCKiT diagnostics Ltd: Creation and development of a novel diagnostic tool for stroke patient triage. Fundraising. IP development. Supervision of PhD students.

Metabolomics Scientist

Cambridge (UK), Feb 2018 – Oct 2018. Owlstone Medical Ltd: Ideation and Clinical testing of a breath test for lung cancer screening.

Visiting Researcher at Tel Aviv University

Israel, Apr 2014 – Jun 2014. Eytan Ruppin’s Laboratory. Genome-scale metabolic modeling of cancer.

Mass Spectrometry Specialist and Manager of Metabolomics Facility

Cambridge (UK), Sep 2012 – Sep 2014. Hutchison/MRC Research Centre, Cancer Unit - Dr C. Frezza lab: Investigation of altered metabolism in several diseases. Discovery of metabolic markers for disease diagnosis. Understanding metabolic liabilities of cancer for novel therapeutic applications.

Education

PhD Student

Cambridge (UK), Oct 2014 – Dec 2017. University of Cambridge - Hutchison/MRC Research Centre, Cancer Unit - Dr C. Frezza lab: Investigation of altered mitochondrial metabolism in cancer initiation and progression. Discovery of alternative mitochondrial therapeutics in cancer.

MSc in Medical and Molecular Biotechnology

Milan (Italy), Oct 2009 – Mar 2012. Vita-Salute San Raffaele University - Medical Biotechnology program: Metabolomics investigation of neural stem cells phenotype. Focus on the development and maintenance of R-software package for metabolomics bioinformatics data analysis. Full grades (110/110).

BSc in Pharmaceutical Biotechnology

Milan (Italy), Oct 2006 – Sep 2009. Vita-Salute San Raffaele University - Medical Biotechnology program: Full grades (107/110).

Scholarships and Grants

  • Innovate UK COVID Continuity Grant (2020). Funds obtained: £65,000. To recruit blood samples from stroke patients in US centres
  • Innovate UK Precision Medicine (2018). Funds obtained: £965,000. To develop a novel diagnostic tool for stroke subtype identification
  • Marie Curie Individual Fellowship, Society and Enterprise (2018). Establish collaboration between University and Enterprise
  • MRC DTP scholarship (2014). 4-year PhD funding
  • Anna Laura Segre fellowship (2012). To perform metabolomics analysis of mouse brain upon stroke induction

Honors and Awards

  • Santander Universities Entrepreneurship Award (2018). Funds obtained: £15,000. Start funding for POCKiT diagnostics Ltd
  • Best presentation, Hutchison/MRC Annual Retreat, (2017).
  • Travel fellowship, EACR Conference, Bilbao, Spain, (2016).

Publications

Research articles and literature reviews:

1 First (co-) author. Sorted by date of publication\

  • Gaude1,c et al. Targeted breath analysis: exogenous volatile organic compounds (EVOC) as metabolic pathway-specific probes. Journal of Breath Research, 2019
  • Antoniou1,c, Gaude1,c et al. The potential of breath analysis to improve outcome for patients with lung cancer. Journal of Breath Research, 2019
  • Lord et al. Integrated pharmacodynamic analysis identifies two metabolic adaption pathways to metformin in breast cancer. Cell Metabolism, 2018\ Gammage et al. Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo. Nature Medicine, 2018
  • Drusian et al. mTORC1 Upregulation Leads to Accumulation of the Oncometabolite Fumarate in a Mouse Model of Renal Cell Carcinoma. Cell reports, 2018
  • Putker et al. Mammalian circadian period, but not phase and amplitude, is robust against redox and metabolic perturbations. Antioxidants & redox signaling, 2018
  • Gaude1,c et al. NADH shuttling couples cytosolic reductive carboxylation of glutamine with glycolysis in cells with mitochondrial dysfunction. Molecular cell, 2018
  • van der Schee et al. Breath biopsy for early detection and precision medicine in cancer. ecancermedicalscience, 2018
  • Tyrakis et al. Fumarate hydratase loss causes combined respiratory chain defects. Cell reports, 21(4), 2018
  • Valcarcel-Jimenez1,c, Gaude1,c et al. Mitochondrial Metabolism: Yin and Yang for Tumor Progression. Trends in Endocrinology & Metabolism, 2017
  • Iraci1,c, Gaude1,c et al. Extracellular vesicles are independent metabolic units with asparaginase activity. Nature chemical biology, 2017
  • Drago et al. Metabolic determinants of the immune modulatory function of neural stem cells. Journal of neuroinflammation, 2017
  • Gaude1,c et al. Tissue-specific and convergent metabolic transformation of cancer correlates with metastatic potential and patient survival. Nature communications, 2017
  • Sciacovelli et al. Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition. Nature, 2016\
  • Gammage et al. Near-complete elimination of mutant mtDNA by iterative or dynamic dose-controlled treatment with mtZFNs. Nucleic acids research, 2016
  • Burrows et al. Hypoxia-induced nitric oxide production and tumour perfusion is inhibited by pegylated arginine deiminase (ADI-PEG20). Scientific reports, 2016
  • Kerr et al. Mutant Kras copy number defines metabolic reprogramming and therapeutic susceptibilities. Nature, 2016
  • Rodenhizer et al. A three-dimensional engineered tumour for spatial snapshot analysis of cell metabolism and phenotype in hypoxic gradients. Nature materials, 2016
  • Catanzaro et al. Inhibition of glucose-6-phosphate dehydrogenase sensitizes cisplatin-resistant cells to death. Oncotarget, 2015
  • Tannahill et al. Metabolic reprograming of mononuclear phagocytes in progressive multiple sclerosis. Frontiers in immunology, 2015
  • Zheng et al. Fumarate induces redox-dependent senescence by modifying glutathione metabolism. Nature communications, 2015
  • Gaude1,c et al. Defects in mitochondrial metabolism and cancer. Cancer & metabolism, 2014
  • Yizhak1,c, Gaude1,c et al. Phenotype-based cell-specific metabolic modeling reveals metabolic liabilities of cancer. Elife, 2014
  • Chouchani1,c et al. Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. Nature, 2014
  • Clark et al. Germline FH mutations presenting with pheochromocytoma. The Journal of Clinical Endocrinology & Metabolism, 2014
  • Zecchini et al. Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer. The EMBO journal, 2014
  • Sciacovelli1,c, Gaude1,c et al. The metabolic alterations of cancer cells. In Methods in enzymology 2014
  • Drago et al. The stem cell secretome and its role in brain repair. Biochimie, 2013
  • Peruzzotti-Jametti et al. Safety and efficacy of transcranial direct current stimulation in acute experimental ischemic stroke. Stroke, 2013
  • Gaude1,c et al. muma, An R package for metabolomics univariate and multivariate statistical analysis. Current Metabolomics, 2013

Patents

  • Human asparaginase lacking glutaminase activity. WO2018050918A1. Inventors: Stefano Pluchino, Christian Frezza, Edoardo Gaude, Tommaso Leonardi, Nunzio Iraci.
  • Method for Diagnosing Stroke caused by Large Vessel Occlusion. 2005632.1. Inventors: Edoardo Gaude, Marcos Ladreda Mochales, Gonzalo Ladreda Mochales.

Others

Skills

  • Languages: English (full proficiency), Spanish (basic), Italian (mother tongue)\
  • Programming: R, Matlab, LaTex
  • Teaching: Supervision of 2 MSc students and 1 PhD thesis
  • Fields of research/interest: metabolism, cancer therapeutics, clinical neuroscience, bioinformatics, metabolic modelling, clinical diagnostics

Contracts

  • Scientist Contractor with Owlstone Medical Ltd.

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